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The overall rate of serum transaminase elevations of more than 8 times the upper limit of normal was approximately 1% in fluconazole-treated patients in clinical trials. Treatment should be continued until clinical parameters or laboratory tests indicate that active fungal infection has subsided. The psychomotor effects of midazolam were significantly increased after oral administration of midazolam but not significantly affected following intravenous midazolam.

The recommended duration of treatment for initial therapy  of cryptococcal meningitis is 10–12 weeks after the cerebrospinal fluid becomes culture negative. Clinical cure at the end of treatment was reported for 86% of fluconazole treated patients compared to 46% of nystatin treated patients. Careful monitoring of phenytoin concentrations in patients receiving DIFLUCAN and phenytoin is recommended. In both, the results of the fluconazole regimen were comparable to the control regimen (clotrimazole or miconazole intravaginally for 7 days) both clinically and statistically at the one month post-treatment evaluation. A third study evaluated the potential interaction of once weekly dosing of fluconazole 300 mg to 21 normal females taking an oral contraceptive containing ethinyl estradiol and norethindrone.



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  • Recent Updates

    21.08.2017

    In a pharmacokinetic interaction study, coadministration of multiple dose hydrochlorothiazide to healthy volunteers receiving fluconazole increased plasma concentrations of fluconazole by 40%. No significant pharmacokinetic changes have been observed when tacrolimus is given intravenously.

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    17.09.2017

    In some patients, particularly those with serious underlying diseases such as and cancer, changes in renal and hematological function test results and hepatic abnormalities have been observed during treatment with fluconazole and comparative agents, but the clinical significance and relationship to treatment is uncertain. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved Standard-Third Edition.

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    27.08.2017

    DIFLUCAN has been associated with rare cases of serious hepatic toxicity, including fatalities primarily in patients with serious underlying medical conditions. In some patients, particularly those with serious underlying diseases such as and cancer, changes in renal and hematological function test results and hepatic abnormalities have been observed during treatment with fluconazole and comparative agents, but the clinical significance and relationship to treatment is uncertain.

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    17.08.2017

    SINCE ORAL ABSORPTION IS RAPID AND ALMOST COMPLETE, THE DAILY DOSE OF DIFLUCAN (FLUCONAZOLE) IS THE SAME FOR ORAL (TABLETS AND SUSPENSION) AND INTRAVENOUS ADMINISTRATION. The MIC values should be interpreted according to the criteria provided in Table 1.

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    26.09.2017

    Allergic reactions to DIFLUCAN are rare, but they can be very serious if not treated right away by a doctor. The pharmacokinetics of fluconazole are markedly affected by reduction in renal function.

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    09.08.2017

    ERG11 results in the production of high concentrations of the target enzyme, creating the need for higher intracellular drug concentrations to inhibit all of the enzyme molecules in the cell. KOH examination and negative culture for (microbiologic eradication), was 55% in both the fluconazole group and the vaginal products group.

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